Topbp1 protein

Author: mrwf

August undefined, 2024

Web15. jan 2024 · Topoisomerase IIβ-binding protein 1 (TopBP1), which contains nine BRCA1 Carboxyl Terminus (BRCT) motifs in humans, is closely related to DNA replication, cell cycle checkpoint signaling, DNA damage responses, and DSB repair [[15], [16], [17] ]. WebTopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome …

TopBP1 Controls BLM Protein Level to Maintain Genome Stability

Web15. jan 2024 · Topoisomerase IIβ-binding protein 1 (TopBP1) is BRCT domain-containing protein that is required for DNA double-strand break (DSB) repair and DNA damage responses; however, its function during the early stage of spermatogenesis is still unclear. http://www.cancerindex.org/geneweb/TOPBP1.htm pearson dbpr

TopBP1 (D8G4L) Rabbit mAb Cell Signaling Technology

WebDNA topoisomerase II binding protein 1 Predicted location i All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction … WebTOPBP1 is an important scaffold protein that helps orchestrate the cellular response to DNA damage. Although it has been previously appreciated that TOPBP1 can form oligomers, … Web1. máj 2024 · TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. mean girl discount tickets

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1

The CIP2A–TOPBP1 axis safeguards chromosome stability and is …

Web1. okt 2014 · The TopBP1-family of proteins has emerged as playing key roles in a diverse range of cellular pathways. These include the initiation of DNA replication and the activation of the DNA-dependant checkpoints, where mechanistic insights are beginning to elucidate the molecular details. The function of TopBP1 in the regulation of DNA repair and gene ... Web14. nov 2013 · Human TopBP1 is a key mediator protein involved in DNA replication checkpoint control. In this study, we report a specific interaction between TopBP1 and … mean girl characters in moviesWebTOPBP1 protein expression was markedly lower in Topbp1cKO than in control testes (Fig. 1 B). Topbp1 cKO seminiferous tubules exhibited a deficiency of spermatogonia and spermatocytes, and spermatids were rarely seen (Fig. 1 C). Germ cell elimination in MSCI-deficient mutants occurs at mid- pearson darby specter

"Web3. jún 2024 · c Visualization of RBMX and TopBP1 protein using STORM. RBMX and TopBP1 foci were observed under Wide Field and STORM. 2D and representative 3D views were shown. Scale bars, 5 μm in Wide Field ... " - Topbp1 protein

Topbp1 protein

Functions of TopBP1 in preserving genome integrity during mitosis

Web1. feb 2016 · Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human … Web24. feb 2024 · TopBP1 forms nuclear foci and localizes to the sites of DNA damage or the arrested replication forks. Downregulation of TopBP1 leads to reduced cell survival, probably due to increased apoptosis. TopBP1 functions as a transcriptional coactivator by enhancing the human papillomavirus (HPV) transcription/replication factor E2.

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Web19. mar 2015 · In our recent paper “TopBP1 controls BLM protein level to maintain genome stability,” we provided evidence suggesting that TopBP1 has an unexpected role in … Web11. jan 2024 · TOPBP1 is a multi BRCT repeat containing protein that activates ATR at DSBs. Here we have developed an experimental tool, the DMAX system, to study the biochemical …

Web24. máj 2015 · Topoisomerase IIβ binding protein 1 (TopBP1) is an important protein that is involved in signal transduction pathways associated with DNA damage, cell cycle checkpoint control, and DNA repair. In addition, it plays various roles in DNA replication, transcription, and cell division, thereby regulating cell proliferation and apoptosis. Web12. dec 2013 · Human TopBP1 is a key mediator protein involved in DNA replication checkpoint control. In this study, we report a specific interaction between TopBP1 and …

Web12. dec 2013 · Human TopBP1 is a key mediator protein involved in DNA replication checkpoint control. In this study, we report a specific interaction between TopBP1 and … Web11. nov 2024 · We finally describe proof-of-concept experiments that support targeting CIP2A, or its interaction with topoisomerase 2-binding protein 1 (TOPBP1), as an attractive approach for the treatment of...

Web10. jan 2024 · In normal tissues, TopBP1 is mainly detected at low levels in the nuclei of basal layer cells, with a further decrease in differentiated spinous layer cells and granular layer cells. In...

WebTopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR–ATRIP checkpoint kinase complex. We have now determined the crystal structure of the N-terminal region of human TopBP1, revealing an unexpected triple-BRCT ... mean girl full movie freeWeb15. aug 2003 · Secondly, hRad9 interacts with replication and checkpoint protein topoisomerase II beta binding protein 1 (TopBP1) before and after DNA damage, and this interaction is dependent on the COOH-terminal 17 amino acids of hRad9. Overexpression of a COOH-terminally deleted form of hRad9 abolishes the colocalization of TopBP1 to … pearson degree managerDNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. TOPBP1 was first identified as a protein binding partner of DNA topoisomerase-IIβ by a yeast 2-hybrid screen, giving it its name. TOPBP1 is involved in a variety of nuclear specific … Zobraziť viac BRCT domains The TOPBP1 gene encodes a scaffold protein which facilitates interactions between different proteins at specific times and locations. It accomplishes these interactions with … Zobraziť viac • DNA damage repair • Ataxia-telangiectasia mutated and RAD3-related (ATR) • BRCA1 • DNA replication Zobraziť viac DNA damage repair TOPBP1 was first identified as a DNA damage protein through its association with Zobraziť viac Cancer Changes in TOPBP1 gene expression are associated with breast cancer, glioblastoma Zobraziť viac • Yamane K, Tsuruo T (September 1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA" Zobraziť viac mean girl charactersWeb15. jan 2024 · Topoisomerase IIβ-binding protein 1 (TopBP1), which contains nine BRCA1 Carboxyl Terminus (BRCT) motifs in humans, is closely related to DNA replication, cell … mean girl murders charactersWeb1. máj 2024 · TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome … pearson dental supply incWeb4. nov 2024 · The TopBP1/PHF8 interaction is mediated by the BRCT 7+8 domain of TopBP1 and phosphorylation of PHF8 at Ser854. This interaction is cell-cycle regulated and … pearson denim scout jacketWebTopoisomerase II Binding Protein 1 (TopBP1) contains eight BRCT domains, which facilitate interaction with various proteins, phosphopeptides, and DNA. Through these interactions, … mean girl characters names