WebJul 13, 2024 · Introduction. CD8 + T cells play a key role in the suppression of viral infections through recognition of short viral peptides presented in complex with human leukocyte antigen (HLA) class-I glycoproteins (HLA-A, -B, and -C). While individual HLA class-I alleles can present thousands of unique peptides (Hunt et al., 2007; Vita et al., 2024), and viral …
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WebJan 7, 2024 · Generally, three typical processes are implemented in NGS-based HLA genotyping: (a) reads alignment toward known HLA reference sequences, such as IMGT/HLA sequence database; (b) candidate HLA alleles identification through assembling the aligned reads into contigs; and (c) HLA allele pair inference by scoring the coverage … WebFeb 24, 2024 · The classical HLA loci (human leukocyte antigen, the human MHC) encode the most variable proteins in the human genome with more than 35,000 alleles ( 14 ). Polymorphic residues in the HLA …
WebMar 20, 2024 · As for HLA supertypes, several studies found associations between class I HLA-B and measles humoral vaccine responses. 24, 27, 28 Supertype B7 was more frequent in sero- and hyperseropositive subjects, and B44 was less frequent in hyper-seropositives and associated with seronegativity, after one dose of MMR. 24, 28 … WebJun 16, 2016 · HLAsupE consists of six interrelated data blocks: (1) HLA supertype-specific epitope data: the restriction of promiscuous epitopes to HLA molecules within one supertype and basic information on the epitopes (e.g., sequence, source protein and organism); (2) HLA supertype-specific binding peptide data: the cross-binding abilities of …
WebJan 1, 2024 · HLA class I proteins, a critical component in adaptive immunity, bind and present intracellular Ags to CD8+ T cells. The extreme polymorphism of HLA genes and associated peptide binding specificities leads to challenges in various endeavors, including neoantigen vaccine development, disease association studies, and HLA typing. WebMay 5, 2009 · We studied the association between measures of cellular (cytokine and frequency of cytokine-secreted cells) immune responses and HLA haplotypes (with frequencies of ≥1%) and supertypes among 738 healthy children following two doses of rubella vaccine.
WebBjörn Kolbeck is an academic researcher from Free University of Berlin. The author has contributed to research in topic(s): Support vector machine & Least squares support vector machine. The author has an hindex of 1, co-authored 1 publication(s) receiving 17 citation(s).
WebHuman leukocyte antigen class I (HLA-I) molecules are highly polymorphic peptide receptors, which select and present endogenously derived peptide epitopes to CD8+ cytotoxic T cells (CTL). The specificity of the HLA-I system is an important component of the overall specificity of the CTL immune system. chlorthalidone constipationα1 and 2 chain residues comprising the B and F peptide-binding pockets of 945 HLA A and B class I molecules were extracted and aligned. Based on crystallographic studies [1, 4, 6, 8], residues 7, 9, 24, 34, 45, 63, 66, 67, 70, and 99 were considered as comprising the B pocket, which engages the peptide residue … See more Next, we defined the broad chemical specificity associated with the different B and F pockets. Table 1 summarizes the amino acid residues generally … See more As a starting point, we have largely utilized the nine supertype designations derived previously [11, 12], with a few exceptions. These exceptions entail … See more The amino acids comprising the B and F peptide binding pockets were compiled for all alleles for which complete sequence information was available. The … See more Typically, the supertype assignment for a particular allele follows the predominant assignment for other alleles sharing the same serological antigen. With … See more chlorthalidone common side effectsWebJun 16, 2016 · HLAsupE is an integrated database of HLA supertype-specific epitopes (promiscuous T-cell epitopes in the context of HLA supertypes). The source data for the … grava properties windsor ctWebHLA A1, B8, DR3 extended haplotypes in autoimmune chronic hepatitis. Brian Tait. 1989, Gastroenterology. See Full PDF Download PDF. See Full PDF ... chlorthalidone contraindicationsWebThe presence of HLA-A02 supertype was the only HLA-I supertype to be associated with improved OS (HR=0.56, 95% CI 0.34 to 0.93, p=0.023). Conclusion: Our results suggest that homozygosity at ≥1 HLA-I loci is associated with short OS and PFS in patients with advanced non-small cell lung cancer with PDL1 ≥50% treated with single-agent … chlorthalidone contain sulfaWebAn HLA-A3-like supertype (minimally comprised of products from the HLA class I alleles A3, A11, A31, A*3301, and A*6801) has been defined on the basis of (a) structural similarities in the antigen-binding groove, (b) shared main anchor peptide-binding motifs, (c) the identification of peptides cross-reacting with most or all of these molecules, … gravando dvd no windows 10WebRepertoire overlaps between molecules within the same class II supertype were found to be similar in magnitude to what has been observed for HLA class I supertypes. Surprisingly, … gravando tela windows 11